Recently, while working on an issue with Email Delivery on Microsoft Exchange 2007 Service Pack 3 Servers.
Environment: Exchange 2007 Hub & Exchange 2007 Edge Servers separately configured.
Analysis: Further checking on the issue found the following error message on the Exchange Server Messaging Queue:
HOSTS file not used 451 4.4.0 DNS query failed
After a lot of research and wasted hours, I was able to figure out the solution which worked for me. Hoping that this shall also help you.
Solution: Under the Network Binding order, “Network Connections – Advanced – Advanced Settings”, ensure that you have the proper Network Adaptor on the top of the list. You can also consider to disable any unused Network Adaptors on the Servers. This shall be a very good practice.
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